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Ozone contact bar 20151/10/2023 ![]() ![]() The dressing consists of a multilayered structure with gradient porosities to achieve uniform ozone distribution. This work reports on the development of a portable topical ozone therapy system comprised of a flexible and disposable semipermeable dressing connected to a portable and reusable ozone-generating unit via a flexible tube. However, utilization of ozone as a treatment for infected wounds has been challenging thus far due to the need for large equipment usable only in contained, clinical settings. Recently, topical ozone therapy has shown to be a promising alternative approach for treatment of non-healing and infected wounds by providing strong antibacterial properties while stimulating the local tissue repair and regeneration. In addition, the rapid increase of life-threatening antibiotic resistant infections has resulted in challenging wound complications with limited choices of effective therapeutics. Wound-associated infections are a significant and rising health concern throughout the world owing to aging population, prevalence of diabetes, and obesity. 6School of Electrical and Computer Engineering, Purdue University, West Lafayette, IN, United States.5Department of Basic Medical Sciences, Purdue University, West Lafayette, IN, United States.4School of Materials Engineering, Purdue University, West Lafayette, IN, United States.3Department of Comparative Pathobiology, College of Veterinary Medicine, Purdue University, West Lafayette, IN, United States.2School of Mechanical Engineering, Purdue University, West Lafayette, IN, United States.1Birck Nanotechnology Center, Purdue University, West Lafayette, IN, United States.Seleem 3, Babak Ziaie 1,6 and Rahim Rahimi 1,4,6* Alexander Roth 1,2, Ahmed Elkashif 3, Vidhya Selvamani 1,4, Rachel Abigail Stucky 1,5, Mohamed N. ![]()
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